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MolBio3D AFM

The Synthetic Biology QC Workhorse for Your Lab

Single molecule quality control with the MolBio3D AFM, right out of the box! Leverage our expertise to image biomolecules on installation day. Designed to be precise, fast, affordable, and fit in biomedical labs with minimal footprint. Bundled with applications support, installation, training, and sample preparation starter kit. No maintenance contract required. All for $69,000 (discounts available)

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Need a quick image of single molecules?

The MolBio3D AFM is the perfect workhorse for labs in synthetic biology, gene therapy, drug conjugates, and biologics. You synthesized a batch of molecule X (DNA, protein, nanoparticles, …) and need to make sure that the batch is good before spending time and resources working with it. Drop a few microliters on a substrate, dry it, scan it in the MolBio3D and see what you’re working with in less than 30 minutes (including sample preparation). Measure dimensions, check secondary or tertiary structures, spot contaminations, aggregates, or fragments. See the example comparing aliquots from cold storage with a sample that was left out at room temperature for two days. How about that six-month-old aliquot in your freezer? How many freeze-thaw cycle can it take? How reproducible is your synthesis? How clean is your purification process?

fresh M13 dsDNA aliquot

fragmentation after storage at RT

No prior AFM experience required

Cut the turnaround time by doing single molecule quality control yourself with the MolBio3D AFM. By the time you boxed samples for shipping you could have already scanned one, and it would cost you a fraction of the shipping fees! The intuitive design of the MolBio3D allows even AFM novices to prepare, measure, and analyze single-molecule data with minimal training. We have trained many undergraduate students in using these AFMs independently.

Open-architecture AFM design demystifies handling and maintenance.
Probe holder accepts all standard AFM probes and allows probe-exchange in less than one minute.
AFM control software follows a logical progression of steps.
Open-source data analysis software is preloaded.
3D datasets allow extraction of angstrom-scale, quantitative data.
Visualize datasets to create intuitive figures for presentations and reports.

AFM software topography tab with M13 ssDNA

Topography scan tab showing raw data of M13 ssDNA

Works in your lab

The MolBio3D enables single molecule QC in your lab, on your bench. The small footprint and vibration insulation of the MolBio3D allows you to place the AFM in a small bench space in your lab. No more running to the basement, just turn around and start a scan. Prepare a sample and scan while doing other work at your desk.

Minimal footprint of 16″ x 17″ x 24″ on a bench plus space for AFM control PC.
Powered by one standard 110V outlet.
Vibration insulation box with passive table can be placed on a sturdy lab bench.
AFM control mini PC, Ebox, and monitor.
No maintenance contract needed, can be self-maintained with remote support.

The complete MolBio3D system on your bench

Leverages our expertise

Prepare and measure your samples on day one. We measure molecules routinely, why shouldn’t you? Our experience in nanobiology applications coupled with the intuitive design of the MolBio3D makes the integration of AFM in your processes seamless.

Half-day installation and noise floor measurements (target < 30 pm).
1 1/2 days of training in sample preparation and AFM operation using your samples.
Starter kit with tools, substrates, reagents, probes, and reference samples, all preselected to work with your application.
Our applications support gets you started before the AFM arrives.