Specialized Applications

“The most exciting phrase to hear in science, the one that heralds new discoveries, is not ‘Eureka!’ but ‘That’s funny…’“- Isaac Asimov

Curiosity is the root of all discoveries and that is precisely what BioCubic is here to support. AFM is used to measure and visualize so many types of biomaterials for specialized applications that require tweaks to standard protocols. See below for some common and less common examples! If you have suggestions don’t hesitate to reach out through our contact form.

  • atomic force microscopy topography scan of epithelial cell from a cheek swab
    Correlative imaging of cells with the LS-AFM

    When mounted on an inverted light microscope AFMs deliver powerful correlative microscopy data on cells and subcellular features.

    3.8 min read
  • AFM image of M13 bacteriophage double-stranded DNA, 5x5 um scan, topography image with color indexed height
    Imaging DNA with the HR-AFM

    AFMs are the most efficient tool to measure DNA. Dilute a clean DNA sample with a magnesium chloride solution, spread it on mica, wash, air dry and image!

    3.9 min read
  • AFM image of a bacterial biofilm with fimbriae, rendered and shadowed
    AFM vs. TEM and SEM

    How do AFMs compare with TEM and SEM in life sciences? These three microscope technologies deliver complementary information, with AFM being unique in its ability to deliver quantitative 3D and nanomechanical data in liquids.

    1.9 min read
  • What makes AFM so special?

    AFM is the simplest, most affordable imaging tool for education, research and quality control at the nanoscale. Why aren't we using it more?

    3.6 min read
  • How the AFM teaches serendipity using eggshells!

    Why we need to teach serendipity in education and research and how an AFM can help!

    5.6 min read